Uniquely structured indole alkaloid compounds are presented that are useful for pain treatment and other therapeutic effects with reduced adverse side effects compared to prior alkaloid analgesics such as morphine and morphine derivatives.
According to various embodiments, indole alkaloid derivatives are provided having an opioid receptor agonistic effect. The indole alkaloid compounds of the present teachings have a useful pharmacological profile for producing potent antinociceptive effects with fewer rewarding effects compared with .mu.-agonists in general, and weaker adverse side effects, such as in terms of IGIT, than morphine in particular.
