Kratom’s reputed pain-relief benefits could come from one of its metabolites

Credit: American Chemical Society

Kratom is a Southeast Asian tree with a long history of use in traditional medicine. In the region, the plant’s leaves are widely consumed for pain relief, treatment of opioid addiction and other uses. Though its efficacy and safety are unproven, kratom use has spread to the U.S. and Europe. Now, researchers report in clomid canada no prescription research proposal sample apa how to wirte report https://www.go-gba.org/2865-fashion-essay/ first essay https://childrenofthecaribbean.org/plan/essay-my-mother-sacrifice/05/ legal 100 mg viagra super follow url viagra rxlist follow url https://thejeffreyfoundation.org/newsletter/writing-a-three-paragraph-essay/17/ literary essay of shakespear document control resume objective go to site apa research paper buy cialis viagra heartburn how to write a check with 0 cents see url help do my homework essay on rabindranath tagore in hindi go here https://nyusternldp.blogs.stern.nyu.edu/how-to-write-a-cover-letter-for-a-job-you-already-interviewed-for/ cialis benefits how to put pdf files on my ipad https://chanelmovingforward.com/stories/popular-masters-essay-editing-site-usa/51/ here http://wnpv1440.com/teacher/tu-thesis-guidelines/33/ http://v-nep.org/classroom/business-case-study-format-example/04/ help write my essay the crucible essay prompts research paper introduction help https://vaccinateindiana.org/viagra-50-side-effects-5597/ ACS Central Science that a metabolite of a kratom alkaloid could be responsible for the treatment’s therapeutic effects.

Currently, kratom is legal and available in the U.S. as a gray-market product, but it has an uncertain regulatory future. In the meantime, scientists are investigating the substance’s . Some prior research attributed these effects to mitragynine, the major active alkaloid in kratom, and its binding to an opioid receptor. However, 7-hydroxymitragynine (7-OH), another alkaloid present in the leaf at far lower concentrations, also interacts with that receptor. To clear up the matter, Jonathan A. Javitch, Susruta Majumdar, Dalibor Sames and colleagues set out to probe the pharmacological and metabolic mechanisms behind kratom’s .

Through studies in cells and mice, the researchers showed that most of the analgesic effect is from 7-OH rather than mitragynine. They also found that metabolism of mitragynine in mouse and human liver preparations actually produces much more 7-OH than is present naturally in kratom. The team says that the results shed light on some of the seemingly contradictory reports on kratom, but more studies are still needed to see whether their findings in mice extend to humans.

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