Kratom Science

A collection of works on the SCIENCE behind kratom.

Please ***NOTE*** This page is a CONSTANT work in progress. We are compiling a full collection of studies per year. If you have something you feel should be added here please contact me at


Kratom: The Science Speaks University of South Florida Video

Yeast Accelerates Discovery: Unlocking Medicinal Compounds In Plants (KRATOM)

Examining the paradoxical effects of kratom: a narrative inquiry

***Survey of Adult Kratom Users in the U.S.

New Phytologist – 2023 – Kim – Biosynthesis of kratom opioids (Mitragynine, an analgesic alkaloid from the plant Mitragyna speciosa (kratom), offers a safer alternative to clinical opioids such as morphine, owing to its more favorable side effect profile.)


***IKA Kratom Science Update OCT 2022

Understanding Kratom Use: A Guide for Healthcare Providers

Current perspectives on the impact of Kratom use

Need for clarity and context in case reports on kratom use, assessment, and intervention

Understanding Kratom Use: A Guide for Healthcare Providers

Kratom use as more than a “self-treatment”

How essential is kratom availability and use during COVID-19? Use pattern analysis based on survey and social media data


Exploring the self-reported motivations of kratom (Mitragyna speciosa Korth.) use: a cross-sectional investigation

Associations of Lifetime Nonmedical Opioid, Methamphetamine, and Kratom Use within a Nationally Representative US Sample


Kratom tea study stirs up new support for relieving opioid dependence

Lyophilized Kratom Tea as a Therapeutic Option for Opioid Dependence


Non-Prescribed Buprenorphine Use Mediates the Relationship between Heroin Use and Kratom Use among a Sample of Polysubstance Users


Abuse liability and therapeutic potential of the Mitragyna speciosa (kratom) alkaloids mitragynine and 7-hydroxymitragynine

**** TAB 13- Yue_-_Abuse_Liability_of_mitragynine



Pharmacology and Legal Status of Kratom

Researcher Suggests Kratom May Have Medical Benefit as Opioid Alternative



Kratom Medical Research


Kratom Studied as Opiate Suppressor

Self-treatment of opioid withdrawal using kratom (Mitragynia speciosa korth)



Total Synthesis of (-)-Mitragynine and Analogues

Kratom and Other Mitragynines: The Chemistry and Pharmacology of Opiods from a Non-Opium Source

Total Synthesis of (-)-Mitragynine and Analogues

Mitragyna speciosa Korth standardized methanol extract induced short-term potentiation of CA1 subfield in rat hippocampal slices

Pharmacology of kratom: an emerging botanical agent with stimulant, analgesic and opioid-like effects.

List of alkaloids identified in Mitragyna speciosa Kratom, and their known or potential activity

Acute Toxicity Study of Standardized Mitragyna speciosa Korth Aqueous Extract in Sprague Dawley Rats

Evaluation of the Effects of Mitragyna speciosa Alkaloid Extract on Cytochrome P450 Enzymes Using a High Throughput Assay

Sedative, Cognitive Impairment and Anxiolytic Effects of Acute Mitragyna Speciosa in Rodents

Ethnophrmacology of Kratom and the Mitragyna Alkaloids

Acute and long-term effects of alkaloid extract of Mitragyna speciosa on food and water intake and body weight in rats.

Pharmacological Studies on 7-Hydroxymitragynine,
Isolated from the Thai Herbal Medicine Mitragyna speciosa:Discovery of an Orally Active Opioid Analgesic

In Vitro and in Vivo Effects of Three Different Mitragyna speciosa Korth Leaf Extracts on Phase II Drug Metabolizing Enzymes—Glutathione Transferases (GSTs)

The neuromuscular blockade produced by pure alkaloid, mitragynine and methanol extract of kratom leaves (Mitragyna speciosa Korth.)


 MITRAGYNA Korthals, Observ. Naucl. Indic. 19. 1839, nom. cons., not Mitragyne R. Brown (1810).

Antidepressant-like effect of mitragynine isolated from Mitragyna speciosa Korth in mice model of depression.


Computational Study on the Conformations of Mitragynine and Mitragynaline


Evaluation of Antioxidant and Antibacterial Activities of Aqueous, Methanolic and Alkaloid Extracts from Mitragyna Speciosa (Rubiaceae Family) Leaves

Simultaneous analysis of mitragynine, 7-hydroxymitragynine, and other alkaloids in the psychotropic plant “kratom” (Mitragyna speciosa) by LC-ESI-MS

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