Acute and long-term effects of alkaloid extract of Mitragyna speciosa on food and water intake and body weight in rats.

Kumarnsit E, et al. Fitoterapia. 2006.

Acute administration of Mitragyna speciosa (MS) extract (45 and 50 mg/kg) significantly resulted in dose-dependent decreases in food and water intakes (P<0.05) in rats. Prolonged suppressing effects were observed following administration of the MS extract (40 mg/kg) for 60 consecutive days. Moreover, the long-term administration also significantly suppressed weight gaining.